Caries prevention with fluoride toothpaste in children:
an update
S. Twetman

ABSTRACT
AIM: This was to review and update knowledge from presently
available systematic reviews of clinical trials on the effect
of fluoride containing gels, mouth rinses and varnishes.
METHODS: The review was based on an electronic search
of three data bases (PubMed 2000 to 2008, EMBASE 2000-
2009, Cochrane 2000-2008) using a search profile similar to
that used in previous Cochrane reviews on the caries-preventive
effect of topical fluoride methods. Only randomized
and semi-randomized trials were included. RESULTS: Four
new studies were identified on fluoride-containing gels, one
on fluoride mouth rinses and four on fluoride-containing varnishes.
Prevented fractions obtained in the permanent dentition
were consistent with the estimates found in previous
reviews, while the effect obtained on caries in the primary
dentition remains uncertain. The only study that compared
the effect of different fluoride compounds, could not find any
difference. CONCLUSIONS: The effect of the three methods
on caries in the permanent dentition is well described, while
the effect on caries in the primary dentition remains to be determined.
The effect of choice of fluoride compound is also
not known.
Key words: caries, children, dentifrice, prevention
Eur Archs Paediatr Dent 2009;10(3):162-167
Dept. of Cariology and Endodontics, Faculty of Health Sciences, University of Copenhagen, Denmark.
Postal address: Prof. S. Twetman., Department of Cariology and Endodontics, Faculty of Health Sciences,
University of Copenhagen, Nørre Allé 20, DK-2200 Copenhagen N, Denmark
Email: stw@odont.ku.dk